Results for 'Leon J. Goldstein'

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  1. Pleasure and pain: Unconditional intrinsic values.Irwin Goldstein - 1989 - Philosophy and Phenomenological Research 50 (December):255-276.
    That all pleasure is good and all pain bad in itself is an eternally true ethical principle. The common claim that some pleasure is not good, or some pain not bad, is mistaken. Strict particularism (ethical decisions must be made case by case; there are no sound universal normative principles) and relativism (all good and bad are relative to society) are among the ethical theories we may refute through an appeal to pleasure and pain. Daniel Dennett, Philippa Foot, R M (...)
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  2. Attitude verbs’ local context.Kyle Blumberg & Simon Goldstein - 2022 - Linguistics and Philosophy 46 (3):483-507.
    Schlenker (Semant Pragmat 2(3):1–78, 2009; Philos Stud 151(1):115–142, 2010a; Mind 119(474):377–391, 2010b) provides an algorithm for deriving the presupposition projection properties of an expression from that expression’s classical semantics. In this paper, we consider the predictions of Schlenker’s algorithm as applied to attitude verbs. More specifically, we compare Schlenker’s theory with a prominent view which maintains that attitudes exhibit belief projection, so that presupposition triggers in their scope imply that the attitude holder believes the presupposition (Karttunen in Theor Linguist 34(1):181, (...)
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  3. Rational Form in Literature.Leon Surette - 1981 - Critical Inquiry 7 (3):612-621.
    W. J. T. Mitchell's "Spatial Form in Literature: Toward a General Theory" (Critical Inquiry 6 [Spring 1980]: 539-67) raises some fundamental questions about the concept of form itself and makes some large claims for the centrality of spatial form not only in modern criticism but in our entire culture. I wish to address a few of the questions raised by his discussion. First, Mitchell posits an identity between spatial form and "synchronic structural models" as if all explanatory models abstracted from (...)
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  4. Moreland on the Impossibility of Traversing the Infinite: A Critique.Felipe Leon - 2011 - Philo 14 (1):32-42.
    A key premise of the kalam cosmological argument is that the universe began to exist. However, while a number of philosophers have offered powerful criticisms of William Lane Craig’s defense of the premise, J.P. Moreland has also offered a number of unique arguments in support of it, and to date, little attention has been paid to these in the literature. In this paper, I attempt to go some way toward redressing this matter. In particular, I shall argue that Moreland’s philosophical (...)
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  5. Contraintes disciplinaires – anciennes et modernes – de l’interprétation logique des Catégories d’Aristote.Gazziero Leone - 2019 - In Véronique Brière & Juliette Lemaire (eds.), Qu'est-ce qu'une catégorie?: interprétations d'Aristote. Louvain-la-Neuve: Peeters. pp. 9-59.
    L. Gazziero, « “Οἰκείως τῇ λογικῇ πραγματείᾳ” (Simplicii in Aristotelis categorias commentarium, 12.11). Contraintes disciplinaires – anciennes et modernes – de l’interprétation logique des Catégories d’Aristote », dans V. Brière et J. Lemaire (éd.), Qu’est-ce qu’une catégorie ? Interprétations d’Aristote, Leuven, Peeters, 2019, p. 9-59 [ISBN 9789042936621] -/- In addition to understanding the very notion of « category » according to its different Aristotelian contexts, the first order of business of an archaeology of Aristotle’s categories is to inquire into its (...)
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  6. How and when are topological explanations complete mechanistic explanations? The case of multilayer network models.Beate Krickel, Leon de Bruin & Linda Douw - 2023 - Synthese 202 (1):1-21.
    The relationship between topological explanation and mechanistic explanation is unclear. Most philosophers agree that at least some topological explanations are mechanistic explanations. The crucial question is how to make sense of this claim. Zednik (Philos Psychol 32(1):23–51, 2019) argues that topological explanations are mechanistic if they (i) describe mechanism sketches that (ii) pick out organizational properties of mechanisms. While we agree with Zednik’s conclusion, we critically discuss Zednik’s account and show that it fails as a general account of how and (...)
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  7. The Epistemology of Cognitive Enhancement.J. Adam Carter & Duncan Pritchard - 2016 - Journal of Medicine and Philosophy (2):220-242.
    A common epistemological assumption in contemporary bioethics held b y both proponents and critics of non-traditional forms of cognitive enhancement is that cognitive enhancement aims at the facilitation of the accumulation of human knowledge. This paper does three central things. First, drawing from recent work in epistemology, a rival account of cognitive enhancement, framed in terms of the notion of cognitive achievement rather than knowledge, is proposed. Second, we outline and respond to an axiological objection to our proposal that draws (...)
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  8. Constraint Accounts of Laws.Meacham Christopher J. G. - forthcoming - Ergo: An Open Access Journal of Philosophy.
    In recent work, Adlam (2022b), Chen & Goldstein (2022), and Meacham (2023) have defended accounts of laws that take laws to be primitive global constraints. A major advantage of these accounts is that they’re able to accommodate the many different kinds of laws that appear in physical theories. In this paper I’ll present these three accounts, highlight their distinguishing features, and note some key differences that might lead one to favor one of these accounts over the others. I’ll conclude (...)
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  9. Coming to Grips with the Queer Festival and Deeper Concerns.Rory J. Conces - 2008 - Bosnia Daily (September 8):9.
    There has been a great deal of talk about the upcoming Queer Festival in Sarajevo. However, the discussion has taken on a bitter tone because some have made much of the fact that the organizers plan to hold the festival during the month of Ramadan. To hold the festival during that time, according to some pious Muslims, is a blasphemous act, one that is rude and disrespectful towards those of the faith. Of course, we must not forget that this festival (...)
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  10. Revolutionary Hope: Essays in Honor of William L. McBride.Nathan J. Jun & Shane Wahl (eds.) - 2013 - Lanham, MD: Lexington Books.
    Over the course of the last four decades, William Leon McBride has distinguished himself as one of the most esteemed and accomplished philosophers of his generation. This volume—which celebrates the occasion of his seventy-fifth birthday—includes contributions from colleagues, friends, and formers students and pays tribute to McBride’s considerable achievements as a teacher, mentor, and scholar.
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  11. The Pasts.Paul A. Roth - 2012 - History and Theory 51 (3):313-339.
    ABSTRACTThis essay offers a reconfiguration of the possibility‐space of positions regarding the metaphysics and epistemology associated with historical knowledge. A tradition within analytic philosophy from Danto to Dummett attempts to answer questions about the reality of the past on the basis of two shared assumptions. The first takes individual statements as the relevant unit of semantic and philosophical analysis. The second presumes that variants of realism and antirealism about the past exhaust the metaphysical options . This essay argues that both (...)
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  12. 5 Questions on Science & Religion.Massimo Pigliucci - 2014 - In Gregg D. Caruso (ed.), Science and Religion: 5 Questions. Automatic Press/VIP. pp. 163-170.
    Are science and religion compatible when it comes to understanding cosmology (the origin of the universe), biology (the origin of life and of the human species), ethics, and the human mind (minds, brains, souls, and free will)? Do science and religion occupy non-overlapping magisteria? Is Intelligent Design a scientific theory? How do the various faith traditions view the relationship between science and religion? What, if any, are the limits of scientific explanation? What are the most important open questions, problems, or (...)
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  13. The moving open future, temporal phenomenology, and temporal passage.Batoul Hodroj, Andrew J. Latham & Kristie Miller - 2024 - Asian Journal of Philosophy 3 (1):1-20.
    Empirical evidence suggests that people naïvely represent time as dynamical (i.e. as containing robust temporal passage). Yet many contemporary B-theorists deny that it seems to us, in perceptual experience, as though time robustly passes. The question then arises as to why we represent time as dynamical if we do not have perceptual experiences which represent time as dynamical. We consider two hypotheses about why this might be: the temporally aperspectival replacement hypothesis and the moving open future hypothesis. We then empirically (...)
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  14. Is future bias a manifestation of the temporal value asymmetry?Eugene Caruso, Andrew J. Latham & Kristie Miller - forthcoming - Philosophical Psychology.
    Future-bias is the preference, all else being equal, for positive states of affairs to be located in the future not the past, and for negative states of affairs to be located in the past not the future. Three explanations for future-bias have been posited: the temporal metaphysics explanation, the practical irrelevance explanation, and the three mechanisms explanation. Understanding what explains future-bias is important not only for better understanding the phenomenon itself, but also because many philosophers think that which explanation is (...)
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  15. Fair Allocation of GLP-1 and Dual GLP-1-GIP Receptor Agonists.Ezekiel J. Emanuel, Johan L. Dellgren, Matthew S. McCoy & Govind Persad - forthcoming - New England Journal of Medicine.
    Glucagon-like peptide-1 (GLP-1) receptor agonists, such as semaglutide, and dual GLP-1 and glucose-dependent insulinotropic polypeptide (GIP) receptor agonists, such as tirzepatide, have been found to be effective for treating obesity and diabetes, significantly reducing weight and the risk or predicted risk of adverse cardiovascular events. There is a global shortage of these medications that could last several years and raises questions about how limited supplies should be allocated. We propose a fair-allocation framework that enables evaluation of the ethics of current (...)
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  16. Grace A. de Laguna’s Theory of Universals: A Powers Ontology of Properties and Modality.A. R. J. Fisher - 2022 - Australasian Philosophical Review 6 (1):39-48.
    In this paper I examine Grace A. de Laguna’s theory of universals in its historical context and in relation to contemporary debates in analytic metaphysics. I explain the central features of her theory, arguing that her theory should be classified as a form of immanent realism and as a powers ontology. I then show in what ways her theory affords a theory of modality in terms of potentialities and discuss some of its consequences along the way.
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  17. A Consolidação da Sociedade Capitalista e a Ciência da Sociedade.Emanuel Isaque Cordeiro da Silva - manuscript
    PREMISSA No século XIX, ocorreram transformações impulsionadas pela emergência de novas fontes energéticas (água e petróleo), por novos ramos industriais e pela alteração profunda nos processos produtivos, com a introdução de novas máquinas e equipamentos. Depois de 300 anos de exploração por parte das nações europeias, iniciou -se, principalmente nas colônias latino-americanas, um processo intenso de lutas pela independência. É no século XIX, já com a consolidação do sistema capitalista na Europa, que se encontra a herança intelectual mais próxima da (...)
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  18. From the History of Physics to the Discovery of the Foundations of Physics,.Antonino Drago - manuscript
    FROM THE HISTORY OF PHYSICS TO THE DISCOVERY OF THE FOUNDATIONS OF PHYSICS By Antonino Drago, formerly at Naples University “Federico II”, Italy – drago@unina,.it (Size : 391.800 bytes 75,400 words) The book summarizes a half a century author’s work on the foundations of physics. For the forst time is established a level of discourse on theoretical physics which at the same time is philosophical in nature (kinds of infinity, kinds of organization) and formal (kinds of mathematics, kinds of logic). (...)
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  19. Mental Time Travel in Animals: The “When” of Mental Time Travel.Andrew J. Latham, Kristie Miller & Rasmus Pedersen - 2024 - Philosophical Transactions of the Royal Society B: Biological Sciences 379 (1913).
    While many aspects of cognition have been shown to be shared between humans and non-human animals, there remains controversy regarding whether the capacity to mentally time travel is a uniquely human one. In this paper, we argue that there are four ways of representing when some event happened: four kinds of temporal representation. Distinguishing these four kinds of temporal representation has five benefits. First, it puts us in a position to determine the particular benefits these distinct temporal representations afford an (...)
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  20. Seeing the Void: Experiencing Emptiness and Awareness with the Headless Way Technique.Brentyn J. Ramm, Anna-Lena Lumma, Terje Sparby & Ulrich Weger - 2024 - Mindfulness 15:958–976.
    Objectives Practitioners in contemplative traditions commonly report experiencing an awareness that is distinct from sensory objects, thoughts, and emotions (“awareness itself”). They also report experiences of a void or underlying silence that is closely associated with this awareness. Subjects who carry out the Headless Way exercises frequently report an experience of emptiness or void at the same time as other contents (void-like experiences). The goals of this study were to (1) assess the reliability of these methods in eliciting the recognition (...)
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  21. What Physicalism Could Be.Michael J. Raven - forthcoming - Analytic Philosophy.
    The physicalist credo is that the world is physical. But some phenomena, such as minds, morals, and mathematics, appear to be nonphysical. While an uncompromising physicalism would reject these, a conciliatory physicalism needn’t if it can account for them in terms of an underlying physical basis. Any such account must refer to the nonphysical. But won’t this unavoidable reference to the nonphysical conflict with the physicalist credo? This essay aims to clarify this problem and introduce a novel solution that relies (...)
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  22. Global Democracy Theories: Reshaping Political Authority.Karel J. Leyva - 2024 - Politics and Rights Review 1.
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  23. Children as Commodity and Changeling: Gender Disappointments and Gender Disappointment.Matthew J. Cull - manuscript
    ‘Gender disappointment’ is regularly reported by those whose child’s sex does not match the sex that they, the parent, desired. With symptoms ranging from mere fleeting sadness to documented cases of serious depression, alienation from one’s child, and emotional suffering, it is clear that so-called ‘gender disappointment’ is a serious issue, that has, as yet, seen little philosophical attention (though see Hendl and Browne 2020). In this chapter I explore gender disappointment, not from the perspective of a parent who ended (...)
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  24. Is Health the Absence of Disease?Somogy Varga & Andrew J. Latham - forthcoming - Inquiry: An Interdisciplinary Journal of Philosophy.
    While philosophical questions about health and disease have attracted much attention in recent decades, and while opinions are divided on most issues, influential accounts seem to embrace negativism about health, according to which health is the absence of disease. Some subscribe to unrestricted negativism, which claims that negativism applies not only to the concepts of health and disease as used by healthcare professionals but also to the lay concept that underpins everyday thinking. Whether people conceptualize health in this manner has (...)
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  25. Kantian Ethics and our Duties to Nonhuman Animals.Samuel J. M. Kahn - 2024 - Between the Species 27 (1):82-107.
    Many take Kantian ethics to founder when it comes to our duties to animals. In this paper, I advocate a novel approach to this problem. The paper is divided into three sections. In the first, I canvass various passages from Kant in order to set up the problem. In the second, I introduce a novel approach to this problem. In the third, I defend my approach from various objections. By way of preview: I advocate rejecting the premise that nonhuman animals (...)
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  26. Easy Practical Knowledge.Timothy Kearl & J. Adam Carter - 2024 - Journal of Philosophy.
    We explore new connections between the epistemologies of mental rehearsal and suppositional reasoning to offer a novel perspective on skilled behavior and its relationship to practical knowledge. We argue that practical knowledge is "easy" in the sense that, by manifesting one's skills, one has a priori propositional justification for certain beliefs about what one is doing as one does it. This proposal has wider consequences for debates about intentional action and knowledge: first, because agents sometimes act intentionally in epistemically hazardous (...)
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  27. Modeling Deep Disagreement in Default Logic.Frederik J. Andersen - 2024 - Australasian Journal of Logic 21 (2):47-63.
    Default logic has been a very active research topic in artificial intelligence since the early 1980s, but has not received as much attention in the philosophical literature thus far. This paper shows one way in which the technical tools of artificial intelligence can be applied in contemporary epistemology by modeling a paradigmatic case of deep disagreement using default logic. In §1 model-building viewed as a kind of philosophical progress is briefly motivated, while §2 introduces the case of deep disagreement we (...)
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  28. Rethinking Sovereignty: A Path to Cosmopolitan Democracy.Karel J. Leyva - 2024 - Politics and Rights Review 2.
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  29. L’altruisme, l’utilitarisme, l’égoïsme et l’idéal de l’homme libre dans la philosophie de Spinoza.Jacques J. Rozenberg - 2024 - Actu Philosophia 3 (Mars 2024):21.
    La question des rapports du spinozisme à l’axiologie a fait l’objet de nombreux débats. Certains commentateurs considèrent Spinoza comme étant profondément immoraliste, alors que pour d’autres, il maintient l'ensemble des valeurs humaines. Spinoza a cherché à dépasser l’utilitarisme propre au conatus de chacun, afin de fonder un altruisme rationnel. Il souligne que le bien auquel l’homme aspire lorsqu’il suit la vertu, il le désirera aussi pour tous les autres hommes. Cependant, les moyens mis en œuvre pour démontrer cette thèse semblent (...)
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  30. What is Mental Health and Disorder? Philosophical Implications from Lay Judgments.Somogy Varga & Andrew J. Latham - 2024 - Synthese (5).
    How do people understand the concepts of mental health and disorder? The objective of this paper is to examine the impact of several factors on people’s judgments about whether a condition constitutes a mental disorder or a healthy state. Specifically, this study examines the impact of the source of the condition, its outcome, individual valuation (i.e., the value the individual attaches to the condition), and group valuation (i.e., the value the relevant group attaches to the condition). While we find that (...)
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  31. Manufactured scarcity and the allocation of scarce resources–Authors' reply.Ezekiel J. Emanuel & Govind Persad - 2024 - The Lancet 403 (10426):532.
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  32. Evolution at the Origins of Life?Ludo L. J. Schoenmakers, Thomas A. C. Reydon & Andreas Kirschning - 2024 - Life 14 (2).
    The role of evolutionary theory at the origin of life is an extensively debated topic. The origin and early development of life is usually separated into a prebiotic phase and a protocellular phase, ultimately leading to the Last Universal Common Ancestor. Most likely, the Last Universal Common Ancestor was subject to Darwinian evolution, but the question remains to what extent Darwinian evolution applies to the prebiotic and protocellular phases. In this review, we reflect on the current status of evolutionary theory (...)
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  33. Introduction: the importance of properties.A. R. J. Fisher & Anna-Sofia Maurin - 2024 - In A. R. J. Fisher & Anna-Sofia Maurin (eds.), The Routledge Handbook of Properties. London: Routledge.
    In this chapter, we introduce the perennial and sometimes sprawling topic of properties, with a brief historical sketch from Ancient to Modern philosophy throughout various cultures and traditions. We argue that the importance of properties can be shown by explaining what explanatory work they can do in philosophical theorising across many areas of philosophy. The chapters in this volume do just that in their specific ways. We also outline the structure of the volume and summarise each Part, first describing the (...)
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  34. The question of secularization : Spinoza, deism and atheism.Jacques J. Rozenberg - 2024 - Sociology International Journal 8 (1):16-21.
    The aim of this article is to bring to light some of the factors that allowed the emergence of secularization, and to understand to what extent and in what ways these factors contributed to the formation of the main lines of Spinozism. I will first examine the issues of secularization, emphasizing the importance of the transformations in the status of the Hebrew language during the Renaissance. I will then analyze the role that the Tractatus theologico-politicus may have had in European (...)
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  35. What, if anything, renders all humans morally equal?Richard J. Arneson - 1999 - In . Blackwell. pp. 103-28.
    All humans have an equal basic moral status. They possess the same fundamental rights, and the comparable interests of each person should count the same in calculations that determine social policy. Neither supposed racial differences, nor skin color, sex, sexual orientation, ethnicity, intelligence, nor any other differences among humans negate their fundamental equal worth and dignity. These platitudes are virtually universally affirmed. A white supremacist racist or an admirer of Adolf Hitler who denies them is rightly regarded as beyond the (...)
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  36. EBL 2024: Editorial Note No. 1.Francisco J. Delgado & Eduardo Gonzalez - 2024 - Economics and Business Letters 13 (1):1-11.
    We start this Volume 13 with the usual Editorial Note reviewing the main features of Economics and Business Letters. EBL is an online letter-type journal, free both for authors and readers, covering all areas of economics and business and with theoretical and empirical letters.
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  37. Ideal Theory, Literary Theory, Whither Transfeminism?Matthew J. Cull - 2025 - In Hilkje Charlotte Hänel & Johanna M. Müller (eds.), The Routledge handbook of non-ideal theory. New York, NY: Routledge.
    In 2005, Charles Mills published “‘Ideal Theory’ as Ideology” in Hypatia: a withering critique of much of contemporary political philosophy and ethics. For Mills such work in philosophy failed to attend to the realities of social life and politics, and in remaining silent on actual issues of domination and oppression served an ideological role in supporting the interests of white bourgeois men. Around the time that Charles Mills launched his broadside against ideal theory, trans theorists had been fighting their own (...)
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  38. Building a Fair Future: Transforming Immigration Policy for Refugees and Families.Matthew J. Lister - 2024 - In Matteo Bonotti & Narelle Miragliotta (eds.), Australian Politics at a Crossroads: Prospects for Change. Routledge. pp. 149-16`.
    In this chapter I focus on two problems facing immigration systems around the world, and Australia in particular. The topics addressed are chosen because each one involves important fundamental rights and because significant improvement in these areas is possible even if each state acts alone, without significant coordination with others. First, I examine refugee programmes, focussing specifically on the ‘two- tier’ refugee programmes pioneered by Australia with the introduction of Temporary Protection Visas by the Howard Government in 1999. Next, I (...)
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  39. A Case for AI Consciousness: Language Agents and Global Workspace Theory.Simon Goldstein & Cameron Domenico Kirk-Giannini - manuscript
    It is generally assumed that existing artificial systems are not phenomenally conscious, and that the construction of phenomenally conscious artificial systems would require significant technological progress if it is possible at all. We challenge this assumption by arguing that if Global Workspace Theory (GWT) — a leading scientific theory of phenomenal consciousness — is correct, then instances of one widely implemented AI architecture, the artificial language agent, might easily be made phenomenally conscious if they are not already. Along the way, (...)
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  40. Forgiveness as a Volitional Commitment.Kathryn J. Norlock - 2023 - In Glen Pettigrove & Robert Enright (eds.), The Routledge Handbook of the Philosophy and Pyschology of Forgiveness. Routledge. pp. 230-242.
    (In The Routledge Handbook of Philosophy and Psychology of Forgiveness, edited by Glen Pettigrove and Robert Enright) This chapter discusses forgiveness conceived as primarily a volitional commitment, rather than an emotional transformation. As a commitment, forgiveness is distal, involving moral agency over time, and can take the form of a speech act or a chosen attitude. The purpose can be a commitment to repair or restore relationships with wrongdoers for their sake or the sake of the relationship, usually by forswearing (...)
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  41. The Aim of Belief and Suspended Belief.C. J. Atkinson - 2021 - Philosophical Psychology 34 (4):581-606.
    In this paper, I discuss whether different interpretations of the ‘aim’ of belief—both the teleological and normative interpretations—have the resources to explain certain descriptive and normative features of suspended belief (suspension). I argue that, despite the recent efforts of theorists to extend these theories to account for suspension, they ultimately fail. The implication is that we must either develop alternative theories of belief that can account for suspension, or we must abandon the assumption that these theories ought to be able (...)
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  42. Language Agents Reduce the Risk of Existential Catastrophe.Simon Goldstein & Cameron Domenico Kirk-Giannini - 2023 - AI and Society:1-11.
    Recent advances in natural language processing have given rise to a new kind of AI architecture: the language agent. By repeatedly calling an LLM to perform a variety of cognitive tasks, language agents are able to function autonomously to pursue goals specified in natural language and stored in a human-readable format. Because of their architecture, language agents exhibit behavior that is predictable according to the laws of folk psychology: they function as though they have desires and beliefs, and then make (...)
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  43. The Epistemic Injustice of Epistemic Injustice.Thomas J. Spiegel - 2022 - Social Epistemology Review and Reply Collective 11 (9):75-90.
    This paper argues that the current discourse on epistemic injustice in social epistemology itself perpetuates epistemic injustice, namely hermeneutic injustice with regards to class and classism. The main reason is that debates on epistemic injustice have foremost focussed on issues related to gender, race, and disability while mostly ignoring class issues. I suggest that this is due to (largely unwarranted) fears about looming class reductionism. More importantly, this is omission is not innocuous, but problematic insofar as it has an unlikely (...)
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  44. Uniqueness and Logical Disagreement.Frederik J. Andersen - 2020 - Logos and Episteme 11 (1):7-18.
    This paper discusses the uniqueness thesis, a core thesis in the epistemology of disagreement. After presenting uniqueness and clarifying relevant terms, a novel counterexample to the thesis will be introduced. This counterexample involves logical disagreement. Several objections to the counterexample are then considered, and it is argued that the best responses to the counterexample all undermine the initial motivation for uniqueness.
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  45. Weighing Aims in Doxastic Deliberation.C. J. Atkinson - 2019 - Synthese (5):4635-4650.
    In this paper, I defend teleological theories of belief against the exclusivity objection. I argue that despite the exclusive influence of truth in doxastic deliberation, multiple epistemic aims interact when we consider what to believe. This is apparent when we focus on the processes involved in specific instances (or concrete cases) of doxastic deliberation, such that the propositions under consideration are specified. First, I out- line a general schema for weighing aims. Second, I discuss recent attempts to defend the teleological (...)
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  46. Vascular-metabolic and GABAergic Inhibitory Correlates of Neural Variability Modulation. A Combined fMRI and PET Study.Timothy J. Lane - 2018 - Neuroscience 379:142-151.
    Neural activity varies continually from moment to moment. Such temporal variability (TV) has been highlighted as a functionally specific brain property playing a fundamental role in cognition. We sought to investigate the mechanisms involved in TV changes between two basic behavioral states, namely having the eyes open (EO) or eyes closed (EC) in vivo in humans. To these ends we acquired BOLD fMRI, ASL, and [18F]-fluoro-deoxyglucose PET in a group of healthy participants (n = 15), along with BOLD fMRI and (...)
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  47. Color constancy: Phenomenal or projective?Adam J. Reeves, Kinjiro Amano & David H. Foster - 2008 - Perception and Psychophysics 70:219-228.
    Naive observers viewed a sequence of colored Mondrian patterns, simulated on a color monitor. Each pattern was presented twice in succession, first under one daylight illuminant with a correlated color temperature of either 16,000 or 4,000 K and then under the other, to test for color constancy. The observers compared the central square of the pattern across illuminants, either rating it for sameness of material appearance or sameness of hue and saturation or judging an objective property—that is, whether its change (...)
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  48. Indication of dynamic neurovascular coupling from inconsistency between EEG and fMRI indices across sleep–wake states.Timothy J. Lane - 2019 - Sleep and Biological Rhythms 17:423-431.
    Neurovascular coupling (NVC), the transient regional hyperemia following the evoked neuronal responses, is the basis of blood oxygenation level-dependent techniques and is generally adopted across physiological conditions, including the intrinsic resting state. However, the possibility of neurovascular dissociations across physiological alterations is indicated in the literature. To examine the NVC stability across sleep–wake states, we used electroencephalography (EEG) as the index of neural activity and functional magnetic resonance imaging (fMRI) as the measure of cerebrovascular response. Eight healthy adults were recruited (...)
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  49. Abnormal Functional Relationship of Sensorimotor Network With Neurotransmitter-Related Nuclei via Subcortical-Cortical Loops in Manic and Depressive Phases of Bipolar Disorder.Timothy J. Lane - 2020 - Schizophrenia Bulletin 46 (1):163–174.
    Objective Manic and depressive phases of bipolar disorder (BD) show opposite psychomotor symptoms. Neuronally, these may depend on altered relationships between sensorimotor network (SMN) and subcortical structures. The study aimed to investigate the functional relationships of SMN with substantia nigra (SN) and raphe nuclei (RN) via subcortical-cortical loops, and their alteration in bipolar mania and depression, as characterized by psychomotor excitation and inhibition. -/- Method In this resting-state functional magnetic resonance imaging (fMRI) study on healthy (n = 67) and BD (...)
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  50. Occipital gamma-aminobutyric acid and glutamate-glutamine alterations in major depressive disorder: An mrs study and meta-analysis.Timothy J. Lane - 2021 - Psychiatry Research: Neuroimaging 308.
    The neurotransmitters GABA and glutamate have been suggested to play a role in Major Depressive Disorder (MDD) through an imbalance between cortical inhibition and excitation. This effect has been highlighted in higher brain areas, such as the prefrontal cortex, but has also been posited in basic sensory cortices. Based on this, magnetic resonance spectroscopy (MRS) was used to investigate potential changes to GABA+ and glutamate+glutamine (Glx) concentrations within the occipital cortex in MDD patients (n = 25) and healthy controls (n (...)
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